Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

Assembly of microtubule-associated protein tau into filamentous inclusions underlies a range of neurodegenerative diseases. Tau filaments adopt different conformations in Alzheimer’s and Pick’s diseases. Here, we used cryo- and immuno- electron microscopy to characterise filaments that were assemble...

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Detalles Bibliográficos
Autores principales: Zhang, Wenjuan, Falcon, Benjamin, Murzin, Alexey G, Fan, Juan, Crowther, R Anthony, Goedert, Michel, Scheres, Sjors HW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375701/
https://www.ncbi.nlm.nih.gov/pubmed/30720432
http://dx.doi.org/10.7554/eLife.43584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375701/
https://www.ncbi.nlm.nih.gov/pubmed/30720432
http://dx.doi.org/10.7554/eLife.43584

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