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Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases
Assembly of microtubule-associated protein tau into filamentous inclusions underlies a range of neurodegenerative diseases. Tau filaments adopt different conformations in Alzheimer’s and Pick’s diseases. Here, we used cryo- and immuno- electron microscopy to characterise filaments that were assemble...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375701/ https://www.ncbi.nlm.nih.gov/pubmed/30720432 http://dx.doi.org/10.7554/eLife.43584 |