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Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUT(s) Strain

L-Asparaginase (ASNase) is used in the treatment of acute lymphoblastic leukemia, being produced and commercialized only from bacterial sources. Alternative Saccharomyces cerevisiae ASNase II coded by the ASP3 gene was biosynthesized by recombinant Pichia pastoris MUT(s) under the control of the AOX...

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Detalles Bibliográficos
Autores principales: Rodrigues, David, Pillaca-Pullo, Omar, Torres-Obreque, Karin, Flores-Santos, Juan, Sánchez-Moguel, Ignacio, Pimenta, Marcela V., Basi, Tajindar, Converti, Attilio, Lopes, André M., Monteiro, Gisele, Fonseca, Luís P., Pessoa, Adalberto Jr.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375902/
https://www.ncbi.nlm.nih.gov/pubmed/30800657
http://dx.doi.org/10.3389/fbioe.2019.00016