Three distinct regions of cRaf kinase domain interact with membrane

Raf kinases are downstream effectors of small GTPase Ras. Mutations in Ras and Raf are associated with a variety of cancers and genetic disorders. Of the three Raf isoforms, cRaf is most frequently involved in tumor initiation by Ras. Cytosolic Raf is auto-inhibited and becomes active upon recruitme...

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Detalles Bibliográficos
Autores principales: Prakash, Priyanka, Hancock, John F., Gorfe, Alemayehu A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375958/
https://www.ncbi.nlm.nih.gov/pubmed/30765804
http://dx.doi.org/10.1038/s41598-019-38770-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375958/
https://www.ncbi.nlm.nih.gov/pubmed/30765804
http://dx.doi.org/10.1038/s41598-019-38770-w

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