Novel column generation-based optimization approach for poly-pathway kinetic model applied to CHO cell culture

Mathematical modelling can provide precious tools for bioprocess simulation, prediction, control and optimization of mammalian cell-based cultures. In this paper we present a novel method to generate kinetic models of such cultures, rendering complex metabolic networks in a poly-pathway kinetic mode...

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Detalles Bibliográficos
Autores principales: Hagrot, Erika, Oddsdóttir, Hildur Æsa, Mäkinen, Meeri, Forsgren, Anders, Chotteau, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376161/
https://www.ncbi.nlm.nih.gov/pubmed/30809468
http://dx.doi.org/10.1016/j.mec.2018.e00083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376161/
https://www.ncbi.nlm.nih.gov/pubmed/30809468
http://dx.doi.org/10.1016/j.mec.2018.e00083

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