β-catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancer

K-ras mutation and p53 loss are the most prevalent genetic alterations in pancreatic cancer. In addition to these two alterations, pancreatic tumors frequently contain a third genetic defect. Mutations in the WNT/ß-catenin signaling molecules occur in 15-20% of pancreatic cancer patients and co-exis...

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Detalles Bibliográficos
Autores principales: Kuo, Tzu-Lei, Cheng, Kuang-Hung, Shan, Yan-Shen, Chen, Li-Tzong, Hung, Wen-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376185/
https://www.ncbi.nlm.nih.gov/pubmed/30809277
http://dx.doi.org/10.7150/thno.28201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376185/
https://www.ncbi.nlm.nih.gov/pubmed/30809277
http://dx.doi.org/10.7150/thno.28201

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