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DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds

BACKGROUND: Primary hypoadrenocorticism (Addison’s disease, AD) and symmetrical lupoid onychodystrophy (SLO) are two clinical conditions with an autoimmune etiology that occur in multiple dog breeds. In man, autoimmunity is associated with polymorphisms in immune-related genes that result in a reduc...

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Detalles Bibliográficos
Autores principales: Gershony, Liza C., Belanger, Janelle M., Short, Andrea D., Le, Myly, Hytönen, Marjo K., Lohi, Hannes, Famula, Thomas R., Kennedy, Lorna J., Oberbauer, Anita M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376674/
https://www.ncbi.nlm.nih.gov/pubmed/30783534
http://dx.doi.org/10.1186/s40575-019-0070-7