SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia

BACKGROUND: The differentiation-based therapy for acute promyelocytic leukemia (APL) is an inspiring example for the search of novel strategies aimed at treatment of other subtypes of acute myeloid leukemia (AML). Thus, the discovery of new molecular players in cell differentiation becomes a paramou...

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Detalles Bibliográficos
Autores principales: Pérez-Fernández, Alejandro, López-Ruano, Guillermo, Prieto-Bermejo, Rodrigo, Ijurko, Carla, Díez-Campelo, María, Sánchez-Guijo, Fermín, Hernández-Hernández, Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376690/
https://www.ncbi.nlm.nih.gov/pubmed/30764849
http://dx.doi.org/10.1186/s13046-019-1097-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376690/
https://www.ncbi.nlm.nih.gov/pubmed/30764849
http://dx.doi.org/10.1186/s13046-019-1097-z

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