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Efficient two-step multivariate random effects meta-analysis of individual participant data for longitudinal clinical trials using mixed effects models
BACKGROUND: Mixed effects models have been widely applied in clinical trials that involve longitudinal repeated measurements, which possibly contain missing outcome data. In meta-analysis of individual participant data (IPD) based on these longitudinal studies, joint synthesis of the regression coef...
Autores principales: | Noma, Hisashi, Maruo, Kazushi, Gosho, Masahiko, Levine, Stephen Z., Goldberg, Yair, Leucht, Stefan, Furukawa, Toshi A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376708/ https://www.ncbi.nlm.nih.gov/pubmed/30764757 http://dx.doi.org/10.1186/s12874-019-0676-1 |
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