Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2

BACKGROUND: Nearly 25% of long intergenic non-coding RNAs (lincRNAs) recruit chromatin-modifying proteins (e.g., EZH2) to silence target genes. HOX antisense intergenic RNA (HOTAIR) is deregulated in diverse cancers and could be an independent and powerful predictor of eventual metastasis and death....

Descripción completa

Detalles Bibliográficos
Autores principales: Ren, Yu, Wang, Yun-fei, Zhang, Jing, Wang, Qi-xue, Han, Lei, Mei, Mei, Kang, Chun-sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376746/
https://www.ncbi.nlm.nih.gov/pubmed/30764859
http://dx.doi.org/10.1186/s13148-019-0624-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376746/
https://www.ncbi.nlm.nih.gov/pubmed/30764859
http://dx.doi.org/10.1186/s13148-019-0624-2

Ejemplares similares