Cargando…

Mst1-Hippo pathway triggers breast cancer apoptosis via inducing mitochondrial fragmentation in a manner dependent on JNK–Drp1 axis

BACKGROUND AND OBJECTIVE: Mst1-Hippo pathway and mitochondrial fragmentation participate in the progression of several types of cancers. However, their roles in breast cancer requires investigation. The aim of our study is to determine whether Mst1 overexpression regulates the viability of breast ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ouyang, Hui, Zhou, Enxiang, Wang, Huan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376886/ https://www.ncbi.nlm.nih.gov/pubmed/30809096 http://dx.doi.org/10.2147/OTT.S193787

Ejemplares similares

Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway
por: Wang, Xisong, et al.
Publicado: (2018)

Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner
por: García-Gutiérrez, Lucía, et al.
Publicado: (2022)

DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis
por: Milani, Mateus, et al.
Publicado: (2017)

SRV2 promotes mitochondrial fission and Mst1-Drp1 signaling in LPS-induced septic cardiomyopathy
por: Shang, Xiuling, et al.
Publicado: (2020)

Effect of taurine on the proliferation, apoptosis and MST1/Hippo signaling in prostate cancer cells
por: Song, Xu, et al.
Publicado: (2022)

Roles of the MST1-JNK signaling pathway in apoptosis of colorectal cancer cells induced by Taurine
por: Liu, Zhuoqi, et al.
Publicado: (2018)

Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2
por: Loforese, Giulio, et al.
Publicado: (2016)

Microsporidia Promote Host Mitochondrial Fragmentation by Modulating DRP1 Phosphorylation
por: Luo, Jian, et al.
Publicado: (2022)

NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation
por: Simpson, Cory L., et al.
Publicado: (2021)

Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control
por: Kulaberoglu, Yavuz, et al.
Publicado: (2017)

Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochondrial fission
por: Nolden, Kelsey A., et al.
Publicado: (2023)

Mst1 overexpression combined with Yap knockdown augments thyroid carcinoma apoptosis via promoting MIEF1-related mitochondrial fission and activating the JNK pathway
por: Zhang, Xiaoli, et al.
Publicado: (2019)

The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair
por: Fallahi, Emma, et al.
Publicado: (2016)

Ets1 facilitates EMT/invasion through Drp1-mediated mitochondrial fragmentation in ovarian cancer
por: Ghosh, Deepshikha, et al.
Publicado: (2023)

Retraction Note: Mst1 overexpression combined with Yap knockdown augments thyroid carcinoma apoptosis via promoting MIEF1-related mitochondrial fission and activating the JNK pathway
por: Zhang, Xiaoli, et al.
Publicado: (2023)

Cardiac‐specific Mst1 deficiency inhibits ROS‐mediated JNK signalling to alleviate Ang II‐induced cardiomyocyte apoptosis
por: Cheng, Zheng, et al.
Publicado: (2018)

Cadmium induced Drp1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity
por: Xu, S, et al.
Publicado: (2013)

Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAF(V600E) Melanoma
por: Wieder, Shira Y., et al.
Publicado: (2015)

Drp1‐dependent peptide reverse mitochondrial fragmentation, a homeostatic response in Friedreich ataxia
por: Johnson, Joseph, et al.
Publicado: (2021)

Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling
por: Ni, Lisheng, et al.
Publicado: (2015)

Structural basis of the heterodimerization of the MST and RASSF SARAH domains in the Hippo signalling pathway
por: Hwang, Eunha, et al.
Publicado: (2014)

Coronary Endothelium No-Reflow Injury Is Associated with ROS-Modified Mitochondrial Fission through the JNK-Drp1 Signaling Pathway
por: Chen, Yi, et al.
Publicado: (2021)

Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis
por: Li, Guobing, et al.
Publicado: (2014)

Map of Enteropathogenic Escherichia coli Targets Mitochondria and Triggers DRP-1-Mediated Mitochondrial Fission and Cell Apoptosis in Bovine Mastitis
por: Li, Yanan, et al.
Publicado: (2022)

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis
por: Turunen, S. Pauliina, et al.
Publicado: (2019)

DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2
por: Kwan, Julian, et al.
Publicado: (2016)

Axotomy Induces Drp1-Dependent Fragmentation of Axonal Mitochondria
por: Kedra, Joseph, et al.
Publicado: (2021)

Mst1 and Mst2 kinases: regulations and diseases
por: Qin, Funiu, et al.
Publicado: (2013)

Mst1 promotes mitochondrial dysfunction and apoptosis in oxidative stress-induced rheumatoid arthritis synoviocytes
por: Wang, Yingjie, et al.
Publicado: (2020)

Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation
por: Lim, Jae Ryong, et al.
Publicado: (2020)

Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance
por: Xie, Longlong, et al.
Publicado: (2020)

The Calcineurin-Drp1-Mediated Mitochondrial Fragmentation is Aligned with the Differentiation of c-Kit Cardiac Progenitor Cells
por: Rahman, Attaur, et al.
Publicado: (2022)

The hippo kinases MST1/2 in cardiovascular and metabolic diseases: A promising therapeutic target option for pharmacotherapy
por: Yin, Yunfei, et al.
Publicado: (2023)

Regulation of Neuronal Cell Death by c-Abl-Hippo/MST2 Signaling Pathway
por: Liu, Weizhe, et al.
Publicado: (2012)

Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer
por: Zhao, Liubiqi, et al.
Publicado: (2021)

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
por: Meng, Zhipeng, et al.
Publicado: (2015)

Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1–JNK–DRP1 pathway
por: Lou, Guohua, et al.
Publicado: (2021)

ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis
por: Hu, Jinjiao, et al.
Publicado: (2020)

PDI-mediated S-nitrosylation of DRP1 facilitates DRP1-S616 phosphorylation and mitochondrial fission in CA1 neurons
por: Lee, Duk-shin, et al.
Publicado: (2018)

Loss of AKAP1 triggers Drp1 dephosphorylation-mediated mitochondrial fission and loss in retinal ganglion cells
por: Edwards, Genea, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_51l0rk2i9imcpon1u3c639co55