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Elevated Human Dipeptidyl Peptidase 4 Expression Reduces the Susceptibility of hDPP4 Transgenic Mice to Middle East Respiratory Syndrome Coronavirus Infection and Disease

BACKGROUND: The ongoing Middle East respiratory syndrome coronavirus (MERS-CoV) infections pose threats to public health worldwide, making an understanding of MERS pathogenesis and development of effective medical countermeasures (MCMs) urgent. METHODS: We used homozygous (+/+) and heterozygous (+/−...

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Detalles Bibliográficos
Autores principales: Algaissi, Abdullah, Agrawal, Anurodh S, Han, Song, Peng, Bi-Hung, Luo, Chuming, Li, Fang, Chan, Teh-Sheng, Couch, Robert B, Tseng, Chien-Te K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376904/
https://www.ncbi.nlm.nih.gov/pubmed/30256968
http://dx.doi.org/10.1093/infdis/jiy574