Cargando…

Ornithine decarboxylase antizyme inhibitor 2 (AZIN2) is a signature of secretory phenotype and independent predictor of adverse prognosis in colorectal cancer

Ornithine decarboxylase (ODC) is the rate-limiting enzyme of polyamine synthesis. The two ODC antizyme inhibitors (AZIN1) and (AZIN2) are regulators of the catalytic activity of ODC. While AZIN1 is a regulator of cell proliferation, AZIN2 is involved in intracellular vesicle transport and secretion....

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaprio, Tuomas, Rasila, Tiina, Hagström, Jaana, Mustonen, Harri, Lankila, Petri, Haglund, Caj, Andersson, Leif C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377119/ https://www.ncbi.nlm.nih.gov/pubmed/30768610 http://dx.doi.org/10.1371/journal.pone.0211564

Ejemplares similares

Expression of ODC Antizyme Inhibitor 2 (AZIN2) in Human Secretory Cells and Tissues
por: Rasila, Tiina, et al.
Publicado: (2016)

REG4 Independently Predicts Better Prognosis in Non-Mucinous Colorectal Cancer
por: Kaprio, Tuomas, et al.
Publicado: (2014)

Determinants of the Differential Antizyme-Binding Affinity of Ornithine Decarboxylase
por: Liu, Yen-Chin, et al.
Publicado: (2011)

Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme
por: Matsufuji, Senya, et al.
Publicado: (1995)

Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2
por: Ramos-Molina, Bruno, et al.
Publicado: (2014)

Minimal Antizyme Peptide Fully Functioning in the Binding and Inhibition of Ornithine Decarboxylase and Antizyme Inhibitor
por: Hsieh, Ju-Yi, et al.
Publicado: (2011)

Elevated tumor expression of Astroprincin (FAM171A1) is an independent marker of poor prognosis in colon cancer
por: Kaprio, Tuomas, et al.
Publicado: (2021)

Ornithine decarboxylase antizyme finder (OAF): Fast and reliable detection of antizymes with frameshifts in mRNAs
por: Bekaert, Michaël, et al.
Publicado: (2008)

Critical Factors Governing the Difference in Antizyme-Binding Affinities between Human Ornithine Decarboxylase and Antizyme Inhibitor
por: Liu, Yen-Chin, et al.
Publicado: (2011)

New insights of polyamine metabolism in testicular physiology: A role of ornithine decarboxylase antizyme inhibitor 2 (AZIN2) in the modulation of testosterone levels and sperm motility
por: Lambertos, Ana, et al.
Publicado: (2018)

Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome
por: Beenukumar, R. R., et al.
Publicado: (2015)

The possible dual role of Ang-2 in the prognosis of pancreatic cancer
por: Roos-Mattila, Matilda, et al.
Publicado: (2023)

A comparative study of two PODXL antibodies in 840 colorectal cancer patients
por: Kaprio, Tuomas, et al.
Publicado: (2014)

Podocalyxin is a marker of poor prognosis in colorectal cancer
por: Kaprio, Tuomas, et al.
Publicado: (2014)

Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor
por: Liu, Yen-Chin, et al.
Publicado: (2015)

Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1
por: Wu, Donghui, et al.
Publicado: (2015)

Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3
por: Christensen, Greg L, et al.
Publicado: (2006)

Critical Factors in Human Antizymes that Determine the Differential Binding, Inhibition, and Degradation of Human Ornithine Decarboxylase
por: Hsieh, Ju-Yi, et al.
Publicado: (2019)

EPLIN-β is a novel substrate of ornithine decarboxylase antizyme 1 and mediates cellular migration
por: Li, Dan, et al.
Publicado: (2023)

Target of Rapamycin Mediated Ornithine Decarboxylase Antizyme Modulate Intracellular Putrescine and Ganoderic Acid Content in Ganoderma lucidum
por: Wu, Tao, et al.
Publicado: (2022)

Association between local immune cell infiltration, mismatch repair status and systemic inflammatory response in colorectal cancer
por: Gunnarsson, Ulf, et al.
Publicado: (2020)

The Prognostic Importance of CD20(+) B lymphocytes in Colorectal Cancer and the Relation to Other Immune Cell subsets
por: Edin, Sofia, et al.
Publicado: (2019)

Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer
por: Lanki, Mira, et al.
Publicado: (2019)

N-glycomic Profiling as a Tool to Separate Rectal Adenomas from Carcinomas
por: Kaprio, Tuomas, et al.
Publicado: (2015)

The expression and prognostic value of toll-like receptors (TLRs) in pancreatic cancer patients treated with neoadjuvant therapy
por: Nurmi, Anna Maria, et al.
Publicado: (2022)

Developing a novel FRET assay, targeting the binding between Antizyme-AZIN
por: Ghalali, Aram, et al.
Publicado: (2019)

Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase
por: Lambertos, Ana, et al.
Publicado: (2019)

The prognostic role of tissue TLR2 and TLR4 in colorectal cancer
por: Beilmann-Lehtonen, Ines, et al.
Publicado: (2020)

Knocking out Ornithine Decarboxylase Antizyme 1 (OAZ1) Improves Recombinant Protein Expression in the HEK293 Cell Line
por: Abaandou, Laura, et al.
Publicado: (2018)

Ubiquitin‐independent, Proteasome‐mediated targeted degradation of KRAS in pancreatic adenocarcinoma cells using an engineered ornithine decarboxylase/antizyme system
por: Ma, Yihui, et al.
Publicado: (2018)

N-glycosylation in non-invasive and invasive intraductal papillary mucinous neoplasm
por: Nieminen, Heini, et al.
Publicado: (2023)

High tissue expression of TLRs combined with high density of tumor infiltrating lymphocytes predicts a better prognosis in colorectal cancer patients
por: Beilmann-Lehtonen, Ines, et al.
Publicado: (2023)

Matrix Metalloproteinase 8 Expression in a Tumour Predicts a Favourable Prognosis in Pancreatic Ductal Adenocarcinoma
por: Kaasinen, Mirjami, et al.
Publicado: (2022)

Characterization of an androgen-responsive, ornithine decarboxylase-related protein in mouse kidney
por: Silander, Kristian M., et al.
Publicado: (2017)

Prognostic Values of Tissue and Serum Angiogenic Growth Factors Depend on the Phenotypic Subtypes of Colorectal Cancer
por: Kasurinen, Jussi Herman, et al.
Publicado: (2023)

Impact of histological response after neoadjuvant therapy on podocalyxin as a prognostic marker in pancreatic cancer
por: Eurola, Annika, et al.
Publicado: (2021)

N-glycomic profiling of colorectal cancer according to tumor stage and location
por: Holm, Matilda, et al.
Publicado: (2020)

Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis
por: Arpalahti, Leena, et al.
Publicado: (2018)

A prognostic model for colorectal cancer based on CEA and a 48-multiplex serum biomarker panel
por: Björkman, Kajsa, et al.
Publicado: (2021)

Expression of Antizyme Inhibitor 2 in Mast Cells and Role of Polyamines as Selective Regulators of Serotonin Secretion
por: Kanerva, Kristiina, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_5vhmgel3pt8je5kmc1na49c6og