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SNARE machinery is optimized for ultrafast fusion

SNARE proteins zipper to form complexes (SNAREpins) that power vesicle fusion with target membranes in a variety of biological processes. A single SNAREpin takes about 1 s to fuse two bilayers, yet a handful can ensure release of neurotransmitters from synaptic vesicles much faster: in a 10th of a m...

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Detalles Bibliográficos
Autores principales: Manca, Fabio, Pincet, Frederic, Truskinovsky, Lev, Rothman, James E., Foret, Lionel, Caruel, Matthieu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377469/
https://www.ncbi.nlm.nih.gov/pubmed/30700546
http://dx.doi.org/10.1073/pnas.1820394116