Inhibition of Phosphodiesterase 4 by FCPR03 Alleviates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors and Prevents Dendritic Spine Loss in Mice Hippocampi

BACKGROUND: Phosphodiesterase 4 is a promising target for developing novel antidepressants. However, prototype phosphodiesterase 4 inhibitors show severe side effects, including nausea and vomiting. N-Isopropyl-3-(cyclopropylmethoxy)-4-difluoromethoxy benzamide (FCPR03) is a novel phosphodiesterase...

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Detalles Bibliográficos
Autores principales: Yu, Hui, Zhong, Jiahong, Niu, Bo, Zhong, Qiuping, Xiao, Jiao, Xie, Jinfeng, Lin, Manna, Zhou, Zhongzhen, Xu, Jiangping, Wang, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Regular Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377503/
https://www.ncbi.nlm.nih.gov/pubmed/30407503
http://dx.doi.org/10.1093/ijnp/pyy092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377503/
https://www.ncbi.nlm.nih.gov/pubmed/30407503
http://dx.doi.org/10.1093/ijnp/pyy092

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