Akt methylation by SETDB1 promotes Akt kinase activity and oncogenic functions

Aberrant activation of Akt disturbs proliferation, survival and metabolic homeostasis of various human cancers. Thus, it is critical to understand upstream signaling pathways governing Akt activation. Here, we report that Akt undergoes SETDB1-mediated lysine-methylation to promote its activation, wh...

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Detalles Bibliográficos
Autores principales: Guo, Jianping, Dai, Xiangpeng, Laurent, Benoit, Zheng, Nana, Gan, Wenjian, Zhang, Jian, Guo, Ailan, Yuan, Min, Liu, Pengda, Asara, John M., Toker, Alex, Shi, Yang, Pandolfi, Pier Paolo, Wei, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377565/
https://www.ncbi.nlm.nih.gov/pubmed/30692625
http://dx.doi.org/10.1038/s41556-018-0261-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377565/
https://www.ncbi.nlm.nih.gov/pubmed/30692625
http://dx.doi.org/10.1038/s41556-018-0261-6

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