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Copper-catalyzed remote C(sp(3))–H azidation and oxidative trifluoromethylation of benzohydrazides
The Hofmann-Löffler-Freytag (HLF) reaction is a prototypical example of radical-based remote functionalization of unactivated C(sp(3))–H bond. While 1,5-hydrogen atom transfer (1,5-HAT) of the amidyl radical is thermodynamically favorable and is well-established, the method for the subsequent functi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377619/ https://www.ncbi.nlm.nih.gov/pubmed/30770833 http://dx.doi.org/10.1038/s41467-019-08741-w |