Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels

Mutations that modulate the activity of ion channels are essential tools to understand the biophysical determinants that control their gating. Here, we reveal the conserved role played by a single amino acid position (TM2.6) located in the second transmembrane domain of two-pore domain potassium (K2...

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Detalles Bibliográficos
Autores principales: Ben Soussia, Ismail, El Mouridi, Sonia, Kang, Dawon, Leclercq-Blondel, Alice, Khoubza, Lamyaa, Tardy, Philippe, Zariohi, Nora, Gendrel, Marie, Lesage, Florian, Kim, Eun-Jin, Bichet, Delphine, Andrini, Olga, Boulin, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377628/
https://www.ncbi.nlm.nih.gov/pubmed/30770809
http://dx.doi.org/10.1038/s41467-019-08710-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377628/
https://www.ncbi.nlm.nih.gov/pubmed/30770809
http://dx.doi.org/10.1038/s41467-019-08710-3

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