Lysophosphatidic acid increases mesangial cell proliferation in models of diabetic nephropathy via Rac1/MAPK/KLF5 signaling

Mesangial cell proliferation has been identified as a major factor contributing to glomerulosclerosis, which is a typical symptom of diabetic nephropathy (DN). Lysophosphatidic acid (LPA) levels are increased in the glomerulus of the kidney in diabetic mice. LPA is a critical regulator that induces...

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Detalles Bibliográficos
Autores principales: Kim, Donghee, Li, Hui Ying, Lee, Jong Han, Oh, Yoon Sin, Jun, Hee-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377648/
https://www.ncbi.nlm.nih.gov/pubmed/30770784
http://dx.doi.org/10.1038/s12276-019-0217-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377648/
https://www.ncbi.nlm.nih.gov/pubmed/30770784
http://dx.doi.org/10.1038/s12276-019-0217-3

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