Fhit–Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells

Fhit protein is lost in cancers of most, perhaps all, cancer types; when restored, it can induce apoptosis and suppress tumorigenicity, as shown in vitro and in mouse tumor models in vivo. Following protein cross-linking and proteomics analyses, we characterized a Fhit protein complex involved in tr...

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Detalles Bibliográficos
Autores principales: Druck, Teresa, Cheung, Douglas G., Park, Dongju, Trapasso, Francesco, Pichiorri, Flavia, Gaspari, Marco, Palumbo, Tiziana, Aqeilan, Rami I., Gaudio, Eugenio, Okumura, Hiroshi, Iuliano, Rodolfo, Raso, Cinzia, Green, Kari, Huebner, Kay, Croce, Carlo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377664/
https://www.ncbi.nlm.nih.gov/pubmed/30770797
http://dx.doi.org/10.1038/s41419-019-1414-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377664/
https://www.ncbi.nlm.nih.gov/pubmed/30770797
http://dx.doi.org/10.1038/s41419-019-1414-7

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