Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection

Understanding the role of rare variants is important in elucidating the genetic basis of human disease. Negative selection can cause rare variants to have larger per-allele effect sizes than common variants. Here, we develop a method to estimate the minor allele frequency (MAF) dependence of SNP eff...

Descripción completa

Detalles Bibliográficos
Autores principales: Schoech, Armin P., Jordan, Daniel M., Loh, Po-Ru, Gazal, Steven, O’Connor, Luke J., Balick, Daniel J., Palamara, Pier F., Finucane, Hilary K., Sunyaev, Shamil R., Price, Alkes L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377669/
https://www.ncbi.nlm.nih.gov/pubmed/30770844
http://dx.doi.org/10.1038/s41467-019-08424-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377669/
https://www.ncbi.nlm.nih.gov/pubmed/30770844
http://dx.doi.org/10.1038/s41467-019-08424-6

Ejemplares similares