Biallelic CCM3 mutations cause a clonogenic survival advantage and endothelial cell stiffening

CCM3, originally described as PDCD10, regulates blood‐brain barrier integrity and vascular maturation in vivo. CCM3 loss‐of‐function variants predispose to cerebral cavernous malformations (CCM). Using CRISPR/Cas9 genome editing, we here present a model which mimics complete CCM3 inactivation in cav...

Descripción completa

Detalles Bibliográficos
Autores principales: Schwefel, Konrad, Spiegler, Stefanie, Ameling, Sabine, Much, Christiane D., Pilz, Robin A., Otto, Oliver, Völker, Uwe, Felbor, Ute, Rath, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378188/
https://www.ncbi.nlm.nih.gov/pubmed/30549232
http://dx.doi.org/10.1111/jcmm.14075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378188/
https://www.ncbi.nlm.nih.gov/pubmed/30549232
http://dx.doi.org/10.1111/jcmm.14075

Ejemplares similares