The lysyl oxidase like 2/3 enzymatic inhibitor, PXS‐5153A, reduces crosslinks and ameliorates fibrosis

Fibrosis is characterized by the excessive deposition of extracellular matrix and crosslinked proteins, in particular collagen and elastin, leading to tissue stiffening and disrupted organ function. Lysyl oxidases are key players during this process, as they initiate collagen crosslinking through th...

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Detalles Bibliográficos
Autores principales: Schilter, Heidi, Findlay, Alison D., Perryman, Lara, Yow, Tin T., Moses, Joshua, Zahoor, Amna, Turner, Craig I., Deodhar, Mandar, Foot, Jonathan S., Zhou, Wenbin, Greco, Angelique, Joshi, Amar, Rayner, Benjamin, Townsend, Sarah, Buson, Alberto, Jarolimek, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378217/
https://www.ncbi.nlm.nih.gov/pubmed/30536539
http://dx.doi.org/10.1111/jcmm.14074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378217/
https://www.ncbi.nlm.nih.gov/pubmed/30536539
http://dx.doi.org/10.1111/jcmm.14074

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