Cargando…

Cell‐based high‐throughput screen for small molecule inhibitors of Bax translocation

Aberrant regulation of programmed cell death (PCD) has been tied to an array of human pathologies ranging from cancers to autoimmune disorders to diverse forms of neurodegeneration. Pharmacologic modulation of PCD signalling is therefore of central interest to a number of clinical and biomedical app...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hui, Kelvin Kai‐Wan, Dojo Soeandy, Chesarahmia, Chang, Stephano, Vizeacoumar, Frederick S., Sun, Thomas, Datti, Alessandro, Henderson, Jeffrey T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378228/ https://www.ncbi.nlm.nih.gov/pubmed/30548903 http://dx.doi.org/10.1111/jcmm.14076

Ejemplares similares

High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: Interaction with IQ motif-containing factors
por: Robinson, Tyler JW, et al.
Publicado: (2013)

Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis
por: Vizeacoumar, Franco J., et al.
Publicado: (2010)

Small Molecule Allosteric Inhibitors of BAX
por: Garner, Thomas P., et al.
Publicado: (2019)

High-throughput drug library screening identifies colchicine as a thyroid cancer inhibitor
por: Zhang, Le, et al.
Publicado: (2016)

A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening
por: Jeon, Jouhyun, et al.
Publicado: (2014)

High Throughput Screen for Escherichia coli Twin Arginine Translocation (Tat) Inhibitors
por: Bageshwar, Umesh K., et al.
Publicado: (2016)

High content, high-throughput screening for small molecule inducers of NF-κB translocation
por: Njikan, Samuel, et al.
Publicado: (2018)

Enhancing the throughput and multiplexing capabilities of next generation sequencing for efficient implementation of pooled shRNA and CRISPR screens
por: Islam, Md. Fahmid, et al.
Publicado: (2017)

Enhanced Phosphorylation of Bax and Its Translocation into Mitochondria in the Brains of Individuals Affiliated with Alzheimer’s Disease
por: Henderson, L.E., et al.
Publicado: (2017)

PhenoM: a database of morphological phenotypes caused by mutation of essential genes in Saccharomyces cerevisiae
por: Jin, Ke, et al.
Publicado: (2012)

Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin
por: Charan, R A, et al.
Publicado: (2014)

Evidence for microRNA-31 dependent Bim-Bax interaction preceding mitochondrial Bax translocation during radiation-induced apoptosis
por: Kumar, Ashish, et al.
Publicado: (2015)

Small Molecule Bax Agonists for Cancer Therapy
por: Xin, Meiguo, et al.
Publicado: (2014)

Inhibitors of the Sec61 Complex and Novel High Throughput Screening Strategies to Target the Protein Translocation Pathway
por: Pauwels, Eva, et al.
Publicado: (2021)

Acidification induces Bax translocation to the mitochondria and promotes ultraviolet light-induced apoptosis
por: Yang, Lin, et al.
Publicado: (2007)

Small molecules reveal an alternative mechanism of Bax activation
por: Brahmbhatt, Hetal, et al.
Publicado: (2016)

A High Throughput Screening Assay System for the Identification of Small Molecule Inhibitors of gsp
por: Bhattacharyya, Nisan, et al.
Publicado: (2014)

Discovery of small molecule inhibitors of xyloglucan endotransglucosylase (XET) activity by high-throughput screening
por: Chormova, Dimitra, et al.
Publicado: (2015)

High-throughput screening for small molecule inhibitors of the type-I interferon signaling pathway
por: Yuliantie, Elita, et al.
Publicado: (2018)

High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway
por: Ishii, Seiji, et al.
Publicado: (2017)

A high-throughput effector screen identifies a novel small molecule scaffold for inhibition of ten-eleven translocation dioxygenase 2
por: Palei, Shubhendu, et al.
Publicado: (2022)

A fluorescence-based high-throughput screening method for cytokinin translocation mutants
por: Zhang, Mengyuan, et al.
Publicado: (2020)

p38 Map Kinase Mediates Bax Translocation in Nitric Oxide–Induced Apoptosis in Neurons
por: Ghatan, Saadi, et al.
Publicado: (2000)

The Octyl Ester of Ginsenoside Rh2 Induces Lysosomal Membrane Permeabilization via Bax Translocation
por: Chen, Fang, et al.
Publicado: (2016)

A High-Throughput Screen Reveals New Small-Molecule Activators and Inhibitors of Pantothenate Kinases
por: Sharma, Lalit Kumar, et al.
Publicado: (2015)

A High-Throughput Small Molecule Screen for C. elegans Linker Cell Death Inhibitors
por: Schwendeman, Andrew R., et al.
Publicado: (2016)

High-throughput small molecule screen identifies inhibitors of microsporidia invasion and proliferation in C. elegans
por: Murareanu, Brandon M., et al.
Publicado: (2022)

Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function
por: Ferrer, Pedro Eitz, et al.
Publicado: (2012)

High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines
por: Ghasemi, Farhad, et al.
Publicado: (2018)

RB1 Status in Triple Negative Breast Cancer Cells Dictates Response to Radiation Treatment and Selective Therapeutic Drugs
por: Robinson, Tyler J. W., et al.
Publicado: (2013)

Automated Analysis of NF-κB Nuclear Translocation Kinetics in High-Throughput Screening
por: Di, Zi, et al.
Publicado: (2012)

Pro-apoptotic Bax molecules densely populate the edges of membrane pores
por: Kuwana, Tomomi, et al.
Publicado: (2016)

Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells
por: Sun, Lei, et al.
Publicado: (2011)

Bax Translocation Mediated Mitochondrial Apoptosis and Caspase Dependent Photosensitizing Effect of Ficus religiosa on Cancer Cells
por: Haneef, Jazir, et al.
Publicado: (2012)

Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis
por: Wang, Ping, et al.
Publicado: (2015)

Simulated microgravity induces nuclear translocation of Bax and BCL-2 in glial cultured C6 cells
por: Bonfiglio, Tommaso, et al.
Publicado: (2019)

Identification of Small-Molecule Inhibitors of Brucella Diaminopimelate Decarboxylase by Using a High-Throughput Screening Assay
por: Bie, Pengfei, et al.
Publicado: (2020)

A high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines
por: Flobak, Åsmund, et al.
Publicado: (2019)

Development of a High-Throughput Screening Assay for Small-Molecule Inhibitors of Androgen Receptor Splice Variants
por: Monaghan, Amy E., et al.
Publicado: (2022)

Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries
por: Tseligka, Eirini D., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mb7dtsicm92jf3bqod5dalbrae