Cryo-EM Structure (4.5-Å) of Yeast Kinesin-5–Microtubule Complex Reveals a Distinct Binding Footprint and Mechanism of Drug Resistance

Kinesin-5s are microtubule-dependent motors that drive spindle pole separation during mitosis. We used cryo-electron microscopy to determine the 4.5-Å resolution structure of the motor domain of the fission yeast kinesin-5 Cut7 bound to fission yeast microtubules and explored the topology of the mot...

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Detalles Bibliográficos
Autores principales: von Loeffelholz, Ottilie, Peña, Alejandro, Drummond, Douglas Robert, Cross, Robert, Moores, Carolyn Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378684/
https://www.ncbi.nlm.nih.gov/pubmed/30659798
http://dx.doi.org/10.1016/j.jmb.2019.01.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378684/
https://www.ncbi.nlm.nih.gov/pubmed/30659798
http://dx.doi.org/10.1016/j.jmb.2019.01.011

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