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Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke

At the blood-brain barrier (BBB), laminin-α5 is predominantly synthesized by endothelial cells and mural cells. Endothelial laminin-α5 is dispensable for BBB maintenance under homeostatic conditions but inhibits inflammatory cell extravasation in pathological conditions. Whether mural cell-derived l...

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Detalles Bibliográficos
Autores principales: Nirwane, Abhijit, Johnson, Jessica, Nguyen, Benjamin, Miner, Jeffrey H., Yao, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378751/
https://www.ncbi.nlm.nih.gov/pubmed/30777135
http://dx.doi.org/10.1186/s40478-019-0676-8