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Slow Ca(2+) Efflux by Ca(2+)/H(+) Exchange in Cardiac Mitochondria Is Modulated by Ca(2+) Re-uptake via MCU, Extra-Mitochondrial pH, and H(+) Pumping by F(O)F(1)-ATPase
Mitochondrial (m) Ca(2+) influx is largely dependent on membrane potential (ΔΨ(m)), whereas mCa(2+) efflux occurs primarily via Ca(2+) ion exchangers. We probed the kinetics of Ca(2+)/H(+) exchange (CHE(m)) in guinea pig cardiac muscle mitochondria. We tested if net mCa(2+) flux is altered during a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378946/ https://www.ncbi.nlm.nih.gov/pubmed/30804812 http://dx.doi.org/10.3389/fphys.2018.01914 |