Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

ABCG2 is a multidrug ATP-binding cassette transporter expressed in the plasma membranes of various tissues and tissue barrier [1–4]. It translocates endogenous substrates, affects the pharmacokinetics of many drugs, and has a protective role against a wide array of xenobiotics, including anti-cancer...

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Detalles Bibliográficos
Autores principales: Manolaridis, Ioannis, Jackson, Scott M., Taylor, Nicholas M. I., Kowal, Julia, Stahlberg, Henning, Locher, Kaspar P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379061/
https://www.ncbi.nlm.nih.gov/pubmed/30405239
http://dx.doi.org/10.1038/s41586-018-0680-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379061/
https://www.ncbi.nlm.nih.gov/pubmed/30405239
http://dx.doi.org/10.1038/s41586-018-0680-3

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