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Brain mGluR5 in Shank3B(−/−) Mice Studied With in vivo [(18)F]FPEB PET Imaging and ex vivo Immunoblotting

Although several studies have found that metabotropic glutamate 5 receptor (mGluR5) may play an important role in autism spectrum disorders (ASD), the mechanisms remain unclear. Here, we used a Shank3 gene complete knockout mouse model (Shank3B(−/−)) to explore the change in mGluR5 in the brain. To...

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Detalles Bibliográficos
Autores principales:	Cai, Guohong, Wang, Mengmeng, Wang, Shuailiang, Liu, Yi, Zhao, Yan, Zhu, Yuanyuan, Zhao, Suo, Zhang, Ming, Guo, Baolin, Yao, Han, Wang, Wenting, Wang, Jing, Wu, Shengxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Psychiatry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379301/ https://www.ncbi.nlm.nih.gov/pubmed/30809159 http://dx.doi.org/10.3389/fpsyt.2019.00038

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