Evaluation of the Antiviral Activity of Sephin1 Treatment and Its Consequences on eIF2α Phosphorylation in Response to Viral Infections

The guanabenz derivative Sephin1 has recently been proposed to increase the levels of translation initiation factor 2 (eIF2α) phosphorylation by inhibiting dephosphorylation by the protein phosphatase 1—GADD34 (PPP1R15A) complex. As phosphorylation of eIF2α by protein kinase R (PKR) is a prominent c...

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Detalles Bibliográficos
Autores principales: Fusade-Boyer, Maxime, Dupré, Gabriel, Bessière, Pierre, Khiar, Samira, Quentin-Froignant, Charlotte, Beck, Cécile, Lecollinet, Sylvie, Rameix-Welti, Marie-Anne, Eléouët, Jean-François, Tangy, Frédéric, Lajoie, Barbora, Bertagnoli, Stéphane, Vidalain, Pierre-Olivier, Gallardo, Franck, Volmer, Romain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379315/
https://www.ncbi.nlm.nih.gov/pubmed/30809223
http://dx.doi.org/10.3389/fimmu.2019.00134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379315/
https://www.ncbi.nlm.nih.gov/pubmed/30809223
http://dx.doi.org/10.3389/fimmu.2019.00134

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