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Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response

Serotonin transporter, SERT (SLC64A for solute carrier family 6, member A4), is a twelve transmembrane domain (TMDs) protein that assumes the uptake of serotonin (5-HT) through dissipation of the Na(+) gradient established by the electrogenic pump Na/K ATPase. Abnormalities in 5-HT level and signali...

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Autores principales: Baudry, Anne, Pietri, Mathea, Launay, Jean-Marie, Kellermann, Odile, Schneider, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379337/
https://www.ncbi.nlm.nih.gov/pubmed/30809118
http://dx.doi.org/10.3389/fnins.2019.00091
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author Baudry, Anne
Pietri, Mathea
Launay, Jean-Marie
Kellermann, Odile
Schneider, Benoit
author_facet Baudry, Anne
Pietri, Mathea
Launay, Jean-Marie
Kellermann, Odile
Schneider, Benoit
author_sort Baudry, Anne
collection PubMed
description Serotonin transporter, SERT (SLC64A for solute carrier family 6, member A4), is a twelve transmembrane domain (TMDs) protein that assumes the uptake of serotonin (5-HT) through dissipation of the Na(+) gradient established by the electrogenic pump Na/K ATPase. Abnormalities in 5-HT level and signaling have been associated with various disorders of the central nervous system (CNS) such as depression, obsessive-compulsive disorder, anxiety disorders, and autism spectrum disorder. Since the 50s, SERT has raised a lot of interest as being the target of a class of antidepressants, the Serotonin Selective Reuptake Inhibitors (SSRIs), used in clinics to combat depressive states. Because of the refractoriness of two-third of patients to SSRI treatment, a better understanding of the mechanisms regulating SERT functions is of priority. Here, we review how genetic and epigenetic regulations, post-translational modifications of SERT, and specific interactions between SERT and a set of diverse partners influence SERT expression, trafficking to and away from the plasma membrane and activity, in connection with the neuronal adaptive cell response to SSRI antidepressants.
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spelling pubmed-63793372019-02-26 Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response Baudry, Anne Pietri, Mathea Launay, Jean-Marie Kellermann, Odile Schneider, Benoit Front Neurosci Neuroscience Serotonin transporter, SERT (SLC64A for solute carrier family 6, member A4), is a twelve transmembrane domain (TMDs) protein that assumes the uptake of serotonin (5-HT) through dissipation of the Na(+) gradient established by the electrogenic pump Na/K ATPase. Abnormalities in 5-HT level and signaling have been associated with various disorders of the central nervous system (CNS) such as depression, obsessive-compulsive disorder, anxiety disorders, and autism spectrum disorder. Since the 50s, SERT has raised a lot of interest as being the target of a class of antidepressants, the Serotonin Selective Reuptake Inhibitors (SSRIs), used in clinics to combat depressive states. Because of the refractoriness of two-third of patients to SSRI treatment, a better understanding of the mechanisms regulating SERT functions is of priority. Here, we review how genetic and epigenetic regulations, post-translational modifications of SERT, and specific interactions between SERT and a set of diverse partners influence SERT expression, trafficking to and away from the plasma membrane and activity, in connection with the neuronal adaptive cell response to SSRI antidepressants. Frontiers Media S.A. 2019-02-12 /pmc/articles/PMC6379337/ /pubmed/30809118 http://dx.doi.org/10.3389/fnins.2019.00091 Text en Copyright © 2019 Baudry, Pietri, Launay, Kellermann and Schneider. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Baudry, Anne
Pietri, Mathea
Launay, Jean-Marie
Kellermann, Odile
Schneider, Benoit
Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response
title Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response
title_full Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response
title_fullStr Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response
title_full_unstemmed Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response
title_short Multifaceted Regulations of the Serotonin Transporter: Impact on Antidepressant Response
title_sort multifaceted regulations of the serotonin transporter: impact on antidepressant response
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379337/
https://www.ncbi.nlm.nih.gov/pubmed/30809118
http://dx.doi.org/10.3389/fnins.2019.00091
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