Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIST patient responding to imatinib

Platelet-Derived Growth Factor Receptor Alpha (PDGFRA) mutations occur in approximately 5–7% of gastrointestinal stromal tumours (GIST). Over half of all PDGFRA mutations are represented by the substitution at position 842 in the A-loop of an aspartic acid (D) with a valine (V), recognized as D842V,...

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Detalles Bibliográficos
Autores principales: Nannini, Margherita, Tarantino, Giuseppe, Indio, Valentina, Ravegnini, Gloria, Astolfi, Annalisa, Urbini, Milena, De Leo, Antonio, Santini, Donatella, Ceccarelli, Claudio, Gruppioni, Elisa, Altimari, Annalisa, Castellucci, Paolo, Fanti, Stefano, Di Scioscio, Valerio, Saponara, Maristella, Gatto, Lidia, Pession, Andrea, Martelli, Pier Luigi, Casadio, Rita, Pantaleo, Maria Abbondanza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379366/
https://www.ncbi.nlm.nih.gov/pubmed/30778083
http://dx.doi.org/10.1038/s41598-018-38028-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379366/
https://www.ncbi.nlm.nih.gov/pubmed/30778083
http://dx.doi.org/10.1038/s41598-018-38028-x

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