Low Frequency ALK Hotspots Mutations In Neuroblastoma Tumours Detected By Ultra-deep Sequencing: Implications For ALK Inhibitor Treatment

The ALK tyrosine kinase receptor is oncogenically activated in neuroblastoma. Whereas numerous ALK fusion genes have been reported in different malignancies, in neuroblastoma ALK is mainly activated through point mutations. Three hotspot residues (F1174, F1245, and R1275) account for 85% of mutant A...

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Detalles Bibliográficos
Autores principales: Javanmardi, Niloufar, Fransson, Susanne, Djos, Anna, Sjöberg, Rose-Marie, Nilsson, Staffan, Truvé, Katarina, Kogner, Per, Martinsson, Tommy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379392/
https://www.ncbi.nlm.nih.gov/pubmed/30778092
http://dx.doi.org/10.1038/s41598-018-37240-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379392/
https://www.ncbi.nlm.nih.gov/pubmed/30778092
http://dx.doi.org/10.1038/s41598-018-37240-z

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