Engineered transfer RNAs for suppression of premature termination codons

Premature termination codons (PTCs) are responsible for 10–15% of all inherited disease. PTC suppression during translation offers a promising approach to treat a variety of genetic disorders, yet small molecules that promote PTC read-through have yielded mixed performance in clinical trials. Here w...

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Detalles Bibliográficos
Autores principales: Lueck, John D., Yoon, Jae Seok, Perales-Puchalt, Alfredo, Mackey, Adam L., Infield, Daniel T., Behlke, Mark A., Pope, Marshall R., Weiner, David B., Skach, William R., McCray, Paul B., Ahern, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379413/
https://www.ncbi.nlm.nih.gov/pubmed/30778053
http://dx.doi.org/10.1038/s41467-019-08329-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379413/
https://www.ncbi.nlm.nih.gov/pubmed/30778053
http://dx.doi.org/10.1038/s41467-019-08329-4

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