Membrane charge and lipid packing determine polymyxin-induced membrane damage

With the advent of polymyxin B (PmB) resistance in bacteria, the mechanisms for mcr-1 resistance are of crucial importance in the design of novel therapeutics. The mcr-1 phenotype is known to decrease membrane charge and increase membrane packing by modification of the bacterial outer membrane. We u...

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Detalles Bibliográficos
Autores principales: Khondker, Adree, Dhaliwal, Alexander K., Saem, Sokunthearath, Mahmood, Ahmad, Fradin, Cécile, Moran-Mirabal, Jose, Rheinstädter, Maikel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379423/
https://www.ncbi.nlm.nih.gov/pubmed/30793045
http://dx.doi.org/10.1038/s42003-019-0297-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379423/
https://www.ncbi.nlm.nih.gov/pubmed/30793045
http://dx.doi.org/10.1038/s42003-019-0297-6

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