Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle

Enzymes accelerate the rate of chemical transformations by reducing the activation barriers of uncatalyzed reactions. For signaling enzymes, substrate recognition, binding, and product release are often rate-determining steps in which enthalpy-entropy compensation plays a crucial role. While the nat...

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Detalles Bibliográficos
Autores principales: Wang, Yingjie, V.S., Manu, Kim, Jonggul, Li, Geoffrey, Ahuja, Lalima G., Aoto, Philip, Taylor, Susan S., Veglia, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379427/
https://www.ncbi.nlm.nih.gov/pubmed/30778078
http://dx.doi.org/10.1038/s41467-019-08655-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379427/
https://www.ncbi.nlm.nih.gov/pubmed/30778078
http://dx.doi.org/10.1038/s41467-019-08655-7

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