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Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle
Enzymes accelerate the rate of chemical transformations by reducing the activation barriers of uncatalyzed reactions. For signaling enzymes, substrate recognition, binding, and product release are often rate-determining steps in which enthalpy-entropy compensation plays a crucial role. While the nat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379427/ https://www.ncbi.nlm.nih.gov/pubmed/30778078 http://dx.doi.org/10.1038/s41467-019-08655-7 |