Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis

Sepsis is life-threatening and often leads to acute brain damage. Dexmedetomidine, an α(2)-adrenoceptor agonist, has been reported to possess neuroprotective effects against various brain injury but underlying mechanisms remain elusive. In this study, in vitro and in vivo models of sepsis were used...

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Detalles Bibliográficos
Autores principales: Sun, Yi-Bing, Zhao, Hailin, Mu, Dong-Liang, Zhang, Wenwen, Cui, Jiang, Wu, Lingzhi, Alam, Azeem, Wang, Dong-Xin, Ma, Daqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379430/
https://www.ncbi.nlm.nih.gov/pubmed/30778043
http://dx.doi.org/10.1038/s41419-019-1416-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379430/
https://www.ncbi.nlm.nih.gov/pubmed/30778043
http://dx.doi.org/10.1038/s41419-019-1416-5

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