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Ursolic acid inhibits colistin efflux and curtails colistin resistant Enterobacteriaceae

Colistin resistance in Enterobacteriaceae especially Klebsiella pneumoniae and Escherichia coli is driving the evolution of pan drug resistant strains. Screening a library of 13 plant nutraceuticals led to the identification of acetyl shikonin and ursolic acid, which exhibited synergy with colistin...

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Detalles Bibliográficos
Autores principales: Sundaramoorthy, Niranjana Sri, Mohan, Harihar M., Subramaniam, Shankar, Raman, Thiagarajan, Selva Ganesan, Subramaniapillai, Sivasubamanian, Aravind, Nagarajan, Saisubramanian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379497/
https://www.ncbi.nlm.nih.gov/pubmed/30778773
http://dx.doi.org/10.1186/s13568-019-0750-4