Autophagy induced by SAHA affects mutant P53 degradation and cancer cell survival

Missense mutations in the TP53 gene produce mutant p53 (mutp53) proteins which may acquire oncogenic properties favoring chemoresistance, cell migration, and metastasis. The exploitation of cellular pathways that promote mutp53 degradation may reduce cell proliferation and invasion as well as increa...

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Detalles Bibliográficos
Autores principales: Foggetti, Giorgia, Ottaggio, Laura, Russo, Debora, Mazzitelli, Carlotta, Monti, Paola, Degan, Paolo, Miele, Mariangela, Fronza, Gilberto, Menichini, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379511/
https://www.ncbi.nlm.nih.gov/pubmed/30745455
http://dx.doi.org/10.1042/BSR20181345

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379511/
https://www.ncbi.nlm.nih.gov/pubmed/30745455
http://dx.doi.org/10.1042/BSR20181345

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