Rapid Recapitulation of Nonalcoholic Steatohepatitis upon Loss of Host Cell Factor 1 Function in Mouse Hepatocytes

Host cell factor 1 (HCF-1), encoded by the ubiquitously expressed X-linked gene Hcfc1, is an epigenetic coregulator important for mouse development and cell proliferation, including during liver regeneration. We used a hepatocyte-specific inducible Hcfc1 knockout allele (called Hcfc1(hepKO)) to indu...

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Detalles Bibliográficos
Autores principales: Minocha, Shilpi, Villeneuve, Dominic, Praz, Viviane, Moret, Catherine, Lopes, Maykel, Pinatel, Danièle, Rib, Leonor, Guex, Nicolas, Herr, Winship
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379584/
https://www.ncbi.nlm.nih.gov/pubmed/30559308
http://dx.doi.org/10.1128/MCB.00405-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379584/
https://www.ncbi.nlm.nih.gov/pubmed/30559308
http://dx.doi.org/10.1128/MCB.00405-18

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