Post-mitotic BET-induced reshaping of integrase quaternary structure supports wild-type MLV integration

The Moloney murine leukemia virus (MLV) is a prototype gammaretrovirus requiring nuclear disassembly before DNA integration. In the nucleus, integration site selection towards promoter/enhancer elements is mediated by the host factor bromo- and extraterminal domain (BET) proteins (bromodomain (Brd)...

Descripción completa

Detalles Bibliográficos
Autores principales: Borrenberghs, Doortje, Zurnic, Irena, De Wit, Flore, Acke, Aline, Dirix, Lieve, Cereseto, Anna, Debyser, Zeger, Hendrix, Jelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379647/
https://www.ncbi.nlm.nih.gov/pubmed/30445610
http://dx.doi.org/10.1093/nar/gky1157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379647/
https://www.ncbi.nlm.nih.gov/pubmed/30445610
http://dx.doi.org/10.1093/nar/gky1157

Ejemplares similares