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Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding
Decoding is thought to be governed by a conformational transition in the ribosome—open (off) to closed (on)—that occurs upon codon–anticodon pairing in the A site. Ribosomal ambiguity (ram) mutations increase miscoding and map to disparate regions, consistent with a role for ribosome dynamics in dec...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379664/ https://www.ncbi.nlm.nih.gov/pubmed/30476222 http://dx.doi.org/10.1093/nar/gky1178 |