Cargando…
Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding
Decoding is thought to be governed by a conformational transition in the ribosome—open (off) to closed (on)—that occurs upon codon–anticodon pairing in the A site. Ribosomal ambiguity (ram) mutations increase miscoding and map to disparate regions, consistent with a role for ribosome dynamics in dec...
Autores principales: | Hoffer, Eric D, Maehigashi, Tatsuya, Fredrick, Kurt, Dunham, Christine M |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379664/ https://www.ncbi.nlm.nih.gov/pubmed/30476222 http://dx.doi.org/10.1093/nar/gky1178 |
Ejemplares similares
-
Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability
por: Pavelich, Ian J, et al.
Publicado: (2019) -
Structural basis for reduced ribosomal A-site fidelity in response to P-site codon-anticodon mismatches
por: Nguyen, Ha An, et al.
Publicado: (2023) -
Structural basis for reduced ribosomal A-site fidelity in response to P-site codon–anticodon mismatches
por: Nguyen, Ha An, et al.
Publicado: (2023) -
Epistasis analysis of 16S rRNA ram mutations helps define the conformational dynamics of the ribosome that influence decoding
por: Ying, Lanqing, et al.
Publicado: (2016) -
Molecular basis of ribosome recognition and mRNA hydrolysis by the E. coli YafQ toxin
por: Maehigashi, Tatsuya, et al.
Publicado: (2015)