Human DNA ligase IV is able to use NAD(+) as an alternative adenylation donor for DNA ends ligation

All the eukaryotic DNA ligases are known to use adenosine triphosphate (ATP) for DNA ligation. Here, we report that human DNA ligase IV, a key enzyme in DNA double-strand break (DSB) repair, is able to use NAD(+) as a substrate for double-stranded DNA ligation. In the in vitro ligation assays, we sh...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Shih-Hsun, Yu, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379666/
https://www.ncbi.nlm.nih.gov/pubmed/30496552
http://dx.doi.org/10.1093/nar/gky1202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379666/
https://www.ncbi.nlm.nih.gov/pubmed/30496552
http://dx.doi.org/10.1093/nar/gky1202

Ejemplares similares