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Human DNA ligase IV is able to use NAD(+) as an alternative adenylation donor for DNA ends ligation
All the eukaryotic DNA ligases are known to use adenosine triphosphate (ATP) for DNA ligation. Here, we report that human DNA ligase IV, a key enzyme in DNA double-strand break (DSB) repair, is able to use NAD(+) as a substrate for double-stranded DNA ligation. In the in vitro ligation assays, we sh...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379666/ https://www.ncbi.nlm.nih.gov/pubmed/30496552 http://dx.doi.org/10.1093/nar/gky1202 |