SMYD3 promotes the epithelial–mesenchymal transition in breast cancer

SMYD3 is a methylase previously linked to cancer cell invasion and migration. Here we show that SMYD3 favors TGFβ-induced epithelial–mesenchymal transition (EMT) in mammary epithelial cells, promoting mesenchymal and EMT transcription factors expression. SMYD3 directly interacts with SMAD3 but it is...

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Detalles Bibliográficos
Autores principales: Fenizia, Claudio, Bottino, Cinzia, Corbetta, Silvia, Fittipaldi, Raffaella, Floris, Pamela, Gaudenzi, Germano, Carra, Silvia, Cotelli, Franco, Vitale, Giovanni, Caretti, Giuseppina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379668/
https://www.ncbi.nlm.nih.gov/pubmed/30544196
http://dx.doi.org/10.1093/nar/gky1221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379668/
https://www.ncbi.nlm.nih.gov/pubmed/30544196
http://dx.doi.org/10.1093/nar/gky1221

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