Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

Efficient delivery of therapeutic RNA beyond the liver is the fundamental obstacle preventing its clinical utility. Lipid conjugation increases plasma half-life and enhances tissue accumulation and cellular uptake of small interfering RNAs (siRNAs). However, the mechanism relating lipid hydrophobici...

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Detalles Bibliográficos
Autores principales: Osborn, Maire F, Coles, Andrew H, Biscans, Annabelle, Haraszti, Reka A, Roux, Loic, Davis, Sarah, Ly, Socheata, Echeverria, Dimas, Hassler, Matthew R, Godinho, Bruno M D C, Nikan, Mehran, Khvorova, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379714/
https://www.ncbi.nlm.nih.gov/pubmed/30535404
http://dx.doi.org/10.1093/nar/gky1232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379714/
https://www.ncbi.nlm.nih.gov/pubmed/30535404
http://dx.doi.org/10.1093/nar/gky1232

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