Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter

Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in DNA repair processes. Inhibition of PARP1 in BRCA-mutated cancers has been observed to be clinically beneficial. Recent genome-mapping experiments have identified a non-canonical G-qu...

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Detalles Bibliográficos
Autores principales: Sengar, Anjali, Vandana, J Jeya, Chambers, Vicki S, Di Antonio, Marco, Winnerdy, Fernaldo Richtia, Balasubramanian, Shankar, Phan, Anh Tuân
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379715/
https://www.ncbi.nlm.nih.gov/pubmed/30551210
http://dx.doi.org/10.1093/nar/gky1179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379715/
https://www.ncbi.nlm.nih.gov/pubmed/30551210
http://dx.doi.org/10.1093/nar/gky1179

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