Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

Small interfering RNA (siRNA)-based therapies are proving to be efficient for treating liver-associated disorders. However, extra-hepatic delivery remains challenging, limiting therapeutic siRNA utility. We synthesized a panel of fifteen lipid-conjugated siRNAs and systematically evaluated the impac...

Descripción completa

Detalles Bibliográficos
Autores principales: Biscans, Annabelle, Coles, Andrew, Haraszti, Reka, Echeverria, Dimas, Hassler, Matthew, Osborn, Maire, Khvorova, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379722/
https://www.ncbi.nlm.nih.gov/pubmed/30544191
http://dx.doi.org/10.1093/nar/gky1239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379722/
https://www.ncbi.nlm.nih.gov/pubmed/30544191
http://dx.doi.org/10.1093/nar/gky1239

Ejemplares similares